Tuesday, August 12, 2008

Retinopathy Signals Increased Risk for Coronary Heart Disease Mortality

Retinopathy Signals Increased Risk for Coronary Heart Disease Mortality

Retinopathy may translate to an increased risk for coronary heart disease mortality in people with and without diabetes, according to a study published online in Heart.

Researchers analyzed retinal photographs of nearly 3000 people over age 49. After 12 years, the presence of retinopathy (e.g., microaneurysms, blot- or flame-shaped hemorrhages) was associated with increased risk for CHD mortality in people with and without diabetes (adjusted hazard ratios: 2.2 and 1.3, respectively). The risk from retinopathy alone was similar to that associated with diabetes itself.

The authors note that retinopathy may be a marker of microvascular disease due to vascular endothelial dysfunction, and they conclude that direct ophthalmoscopy may help identify those at increased risk. "Such people," they write, "may benefit from a thorough cardiovascular risk assessment, lifestyle changes and better management of risk factors, and closer monitoring for CHD events."